buy custom The German Peasant Rebellion essay

buy custom The German Peasant Rebellion essay In the article The German Peasant Rebellion, Steven traces the origin of the peasants war not only the economic and social reasons alone. He claims that the roots of the rebellion were intertwined in religious, political and legal problems other than socio-economic reasons solely. The specific socio-economic grievance that took centre stage was the burden that was brought about by the lordship. Komneno cements this by explaining that hard labor services that they provided to their Lords, high housing rents, high tithes, poor accessibility to common resources and serfdom greatly contributed to war being sparked off (Komneno, 2008). Other reasons were high taxes, burdens that were exposed to them due to the development of new states and anticlericalism particularly after mixing with early Reformations evangelical programs. Both articles emphasize the fact that German peasants war was one of the most notable rebellions to happen in the history of modern European. Komneno observes how from 1524-1525, the peasants army shortly shattered the rule of many lords, some princes and most urban governments in what they term as the central and southern locations of the Holy Roman Empire. Thus was aimed at creation revolutionary changes as part of their political program although it did not rise achieve full potential. According to the two articles, the rebellion was not only a Germany affair but it had spread to other parts like those of modern Switzerland, France, northern Italy and Austria. The peasants rebels had a strong admiration for urban reforms and Reformation (Kreis, 2002). Another area in which both articles express similar views is the formation of political organization within the peasants. Komneno reiterates that they formed this in response to challenge the feudal lords. His counterpart, Steven, says that they formed the political origination by assembling communally. This was aggravated by the practices such as division of labor, access to common fields and crop rotation that the villagers had long organized. Due to this they intensified their activities with many rallies, the also formed bands and to some extend federations. Although both articles purely talk about the same thing, there exist some few notable differences between them in terms of their scope. In the article Germany Peasants War, 1524-1525, Steven commences by giving a brief prehistory where he explains how the administration costs rose in early medieval state in early 15th century. This he explains was because of transition in warfare that saw the rulers seek the use of expensive weapons and mercenaries other than the unpaid knights (Kreis, 2002). At the end he talks about the legacy observing that The German Peasants War aided in strengthening the relationship between Lutheran Princes and Lutheran Church because of Martin Luthers open support for authorities against the aggrieved peasants. Both of these features are not observed in Komneno article titled The German peasant rebellion of 1525 displays a slight difference in that other than discussing the political organization of the peasant, he talks about their goal that was of course, t o counter the lordship. Both sources justify the claims and demands that of the peasants by demonstrating the fact they being unfairly treated and oppressed. Komneno says that although part of the atrocities that were committed by peasants were detrimental, the massacre of Weinsberg for example, those that their enemies committed against them were worse. The peasants were later prohibited from hunting, fishing and chopping wood freely as they used to do. This was due to these common lands being taken over by the lords (Komneno, 2008). The Lords could also use the lands of the peasants as they wished. It reached a point when peasants could no not anything but helplessly wild game destroy their crops. The peasants was a justified course to fight against violation of their rights. At the end of the article, Steven observes that authorities had changed their ways and implemented better terms of taxation. They became more careful on handling the peasants as a means of averting a repeat of the revolt. Through this thhe article tries to bring out that the authorities had identified where they went wrong. The peasants languishing in poverty had no other ways of fighting the lordship, the justice was against them hence this was their only justified way to fight back. Whenever any peasant wanted to marry, he/she had to obtain permission from the lords. As if this was not enough, peasants had to a give a marriage tax before doing so. This was a form of regulation that was aimed at regulating their population and collecting the much needed revenue to run the new administrative states. The population growth also amplified the competition for land, compromising harvests in early 1520s; the lords also wanted control the population to avoid more land being used by peasants (Komneno, 2008).. Luther was against the revolts and condemned it calling for the authorities to crush the rebellion with no mercy. Only a few preachers such as Thomas Muntzer gave hope to the rebellion. Some of the peasants were also not of his idea of rejecting the Catholic practices of sacraments, the institution of monasteries and celibacy. This might be as well one of the reason why Luther wanted them demolished. . He termed the peasants as murderers stating that they went against the teachings of the Bible (Komneno, 2008). Luther was also disappointed at them because he says that they had promised to obey the law and instructions but later on they break the promise to rebel. He saw them as pretenders who practiced work of devil. He defended his act of condemning them by stating that he had to expose them for decided to go astray. Luther said that they deserved the double death of both body and for they caused chaos and robbed castles that was not theirs. I dont support Luther for his actions, his deeds was down playing the oppression they underwent in the hands of the cruel lords. Being poor, oppressed and people who the judicial system was against, they had no other way they could fight for their rights. I view their rebellion as justified because in the end, it bore fruits as some measures were put into place to avoid their being heavily taxed. Buy custom The German Peasant Rebellion essay

50 Rhetorical Devices for Rational Writing

50 Rhetorical Devices for Rational Writing 50 Rhetorical Devices for Rational Writing 50 Rhetorical Devices for Rational Writing By Mark Nichol Is rhetorician on your resume? It should be, because I’d be surprised if you haven’t employed one or more of the methods listed below for conveying emphasis to your writing. Rhetoric, the art of persuasive written or spoken discourse, was developed in ancient Greece, and every one of the terms below stems from classical Greek or from Latin, the language of the culture that inherited the Greek oratory legacy. But that should be no obstacle to adding these tried-and-true tools to your argumentative armamentarium, because brief definitions, as well as examples, accompany this exhaustive but by no means complete list: 1. Amplification An expansion of detail to clarify a point: â€Å"We few, we happy few, we band of brothers.† 2. Anacoluthon A sudden break in a sentence’s grammatical structure: â€Å"So, then I pulled up to her house are you still with me here?† 3. Anadiplosis Repetition of words, especially located at the end of one phrase or clause and the beginning of the next: â€Å"I was at a loss for words, words that perhaps would have gotten me into even more trouble.† 4. Anaphora Repetition of one or more words at the head of consecutive phrases, clauses, or sentences: â€Å"I came, I saw, I conquered.† 5. Anastrophe Inversion of word order to mark emphasis: â€Å"Enter the forest primeval.† 6. Antanaclasis Repetition of a word in a sentence in which a different meaning is applied each time: â€Å"If you aren’t fired with enthusiasm, you will be fired, with enthusiasm.† 7. Antanagoge The contradiction of a negative comment with a positive one, as in â€Å"The car wouldn’t start this time, but it least it didn’t catch on fire.† 8. Antimetabole Reversal of repeated words or phrases for effect: â€Å"Ask not what your country can do for you, but what you can do for your country. 9. Antiphrasis Ironic use of a single word: â€Å"It was a cool 100 degrees in the shade.† 10. Antistrophe Repetition of a word or phrase at the close of successive clauses: â€Å"You said he was late true enough. You said he was not prepared true enough. You said he did not defend his statements true enough.† 11. Antithesis Contrast within parallel phrases (not to be confused with the ordinary use of the word to mean â€Å"extreme opposite†): â€Å"Many are called, but few are chosen.† The term can also refer to literary characters who, though not necessarily antagonists, represent opposite personal characteristics or moral views. 12. Apophasis Calling attention to something by dismissing it: â€Å"No one would suggest that those who are homeless elected to live on the streets willingly.† 13. Aporia A statement of hesitation, also known as dubitatio, in which characters express to themselves an actual or feigned doubt or dilemma: â€Å"Should I strike now, or bide my time?† 14. Aposiopesis Abrupt discontinuation of a statement: â€Å"If you say that one more time, I’m gonna † 15. Apostrophe Interruption of thought to directly address a person or a personification: â€Å"So, I ask you, dear reader, what would you have me do?† 16. Asyndeton Absence of conjunctions: â€Å"We cannot dedicate, we cannot consecrate, we cannot hallow this ground.† 17. Auxesis Exaggeration, often with sequential enhancement: â€Å"You found my purse? You are a hero, a prince, a god!† 18. Bdelygmia A rant of abusive language: â€Å"Calling you an idiot would be an insult to stupid people. Are you always this stupid, or are you just making a special effort today?† 19. Bomphiologia Excessive braggadocio: â€Å"I am the very model of a modern major-general. I’ve information vegetable, animal, and mineral.† Also known as verborum bombus. 20. Brachyology An abbreviated expression or telegrammatic statement: â€Å"‘Morning,’ he mumbled as he stumbled out of bed†; â€Å"I have three words for you, buddy: pot, kettle, black.† 21. Cacophony Deliberate use of harsh letter sounds: â€Å"The clash and clang of steel jarred him awake.† 22. Catachresis A hyperbolic metaphor, as in â€Å"Each word was a lightning bolt to his heart.† 23. Chiasmus This is the reversal of grammatical order from one phrase to the next, exemplified in these two well-known quotes about evaluation: â€Å"Judge not, lest ye be judged† and â€Å"A heart is not judged by how much you love, but by how much you are loved by others.† 24. Commoratio Repetition of a point with different wording: â€Å"He’s passed on! This parrot is no more! He has ceased to be! He’s expired and gone to meet his maker!† (etc., ad absurdum) 25. Dehortatio Imperative advice about how not to act: â€Å"Do not look a gift horse in the mouth.† 26. Diacope Repetition of one or more words after the interval of one or more other words: â€Å"People who like this sort of thing will find this the sort of thing they like.† 27. Diatyposis Advice: â€Å"Do unto others as you would have others do unto you.† 28. Distinctio A definition or clarification of a term: â€Å"What we will be seeking . . . will be large, stable communities of like-minded people, which is to say relatives.† 29. Epanelepsis Starting and ending a phrase, clause, or a sentence, or a passage, with the same word or phrase: â€Å"Nothing is worse than doing nothing.† 30. Epistrophe The repetition of a word at the end of each phrase or clause: â€Å"I swear to tell the truth, the whole truth, and nothing but the truth.† 31. Epizeuxis Epizeuxis, epizeuxis, epizeuxis! My favorite new word, also called palilogia, refers to nothing more than the repetition of words: â€Å"To my fifteen-year-old daughter, everything is ‘boring, boring, boring!’† 32. Hendiadys A conjunctive rather than a coordinate phrase: â€Å"I made it nice and hot, just the way you like it.† 33. Hyperbaton Excursion from natural word order in various ways: â€Å"Theirs was a glory unsurpassed†; â€Å"It is a sad story but true.† 34. Hysteron-proteron A reversal of logical order of elements in a phrase: â€Å"Sudden thunder and lightning drove them to shelter.† 35. Litotes This is the strategy of understatement often employed to provide subtle emphasis, frequently for ironic effect or to underline a passionate opinion: â€Å"The assassin was not unacquainted with danger.† 36. Meiosis A dismissive epithet, such as treehugger, or a humorously dismissive understatement (also known as tapinosis), such as the Monty Python and the Holy Grail gem â€Å"It’s just a flesh wound!† 37. Metanoia The qualification of a statement to either diminish or strengthen its tone, as in â€Å"She was disturbed make that appalled by the spectacle.† Traditionally, nay is often a keyword that sets up the shift, but no replaces it in modern usage except in facetious or whimsical writing: â€Å"You are the fairest flower in the garden nay, in the entire meadow.† 38. Paronomasia Punning wordplay, including any of many types, including homophonic or homographic puns, both of which are included in this example: â€Å"You can tune a guitar, but you can’t tuna fish. Unless of course, you play bass.† 39. Pleonasm Redundancy for emphasis: â€Å"We heard it with our own ears.† 40. Polyptoton Repetition of two or more forms of a word; also known as paregmenon: â€Å"You try to forget, and in the forgetting, you are yourself forgotten.† 41. Polysyndeton Insertion of conjunctions before each word in a list: â€Å"My fellow students read and studied and wrote and passed. I laughed and played and talked and failed.† 42. Scesis Onomaton Repetition of an idea using synonymous words or phrases: â€Å"We succeeded, won, and walked away victorious.† 43. Sententia The punctuation of a point with an aphorism such as â€Å"Don’t judge a book by its cover.† 44. Sentential Adverbs These single words or brief phrases emphasize the thought they precede, interrupt, or rarely follow. Examples include however, naturally, no doubt, and of course and, in informal writing, phrases such as â€Å"you see.† 45. Syllepsis Divergent use of a word in two phrases: â€Å"We must all hang together or assuredly we will all hang separately.† 46. Symploce A combination of anaphora and epistrophe: â€Å"To think clearly and rationally should be a major goal for man; but to think clearly and rationally is always the greatest difficulty faced by man.† 47. Synathroesmus A series of adjectives, also known as accumulatio, compiled often in the service of criticism: â€Å"You’re the most arrogant, selfish, self-absorbed, insufferable narcissist I’ve ever met!† 48. Synecdoche Substitution of a part or a substance for a whole, one thing for another, or a specific name used for a generic: â€Å"A hundred head of cattle were scattered throughout the field†; â€Å"A regiment of horse paraded by†; â€Å"The swordsmen unsheathed their steel†; â€Å"Do you have a Kleenex?† 49. Tapinosis Invective: â€Å"Get out of my way, you mouth-breathing cretin.† 50. Tricolon A series of three parallel words, phrases, clauses, or statements: â€Å"Tell me and I forget. Teach me and I remember. Involve me and I learn.† Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Vocabulary category, check our popular posts, or choose a related post below:Fly, Flew, (has) FlownFlied?Top 11 Writing Apps for iOS (iPhone and iPad)Adverbs and Hyphens

Classical Mythology in Abstract Expressionism Essay

Classical Mythology in Abstract Expressionism - Essay Example The essay "Classical Mythology in Abstract Expressionism" investigates classical mythology influence on abstract expressionism. The influences of depicting Classical Mythology begin with the thematic work that is accepted with both Surrealists and Abstract Expressionists during both time frames. The main ideology is based on creating the universal theme of humanism that is a part of every experience. The modern artwork depicts this by taking the mythology and relating it to the human experience by representing the mythology from a different perspective. The ideology was to take the idea of humanism and to create a modern approach to the myths that would combine the poetic expression of the artwork and the humanistic ideologies related to the myths. Instead of the stories representing the ancient and mysterious, both artistic movements created a sense of duality with the mythology. This was dependent on the mysterious and the human that combined together to create a sense of poetic me aning with the artwork. By doing this, artists were able to create a sense of meaning through the subject matter which could be depicted in modern society. The importance of the humanistic approach was not only to express the universal themes of duality between human nature and the myths. This was furthered with the time frame in which the artists were developing the portraits in. Many that were depicting the artwork focused on the social and political agenda of the time, specifically with the movement into modernism. The social and political approach was one which consisted of conflicts in society, stress which many were under because of political agendas and change that was continuously moving forward during this time frame. The themes were based on the tension of those who were living with the humanistic side, as opposed to the political and social agendas based on status, violence and struggle. Depicting these themes became an important aspect of the work in both time frames, sp ecifically because of influences of war, political leaders and social change that continued to move forward through contemporary events and ideas which followed (Bernstock, 1993: 153). An example of the artwork that showed the humanistic side and the social and political stresses came through works such as Andre Masson and Jacques Lipchitz (see Appendix A). The work of Andre Masson, Myth of Sisyphus, shows the French Surrealist viewpoint of conflict and humanism during the time. The myth is depicted by a boulder being rolled up a hill, only to continue to roll back down. This is followed in Greek mythology by a king who moves into power but doesn’t follow through with wisdom, instead ruthlessly killing thousands and betraying the gods. The influence of the 1930s was one which was created through the political agendas leading to war as well as the philosophical belief that there wasn’t meaning behind this. When looking at the painting of Masson, it is able to follow the myth of the ruthless actions and the boulder only going back down the hill. Masson does this by making the boulders appear out of place and time, each which carries the same myth as is depicted in the Greek legends. By doing this, Masson is able to create a link to the political leaders of the myth that deceive the gods to the present day, in which the same

Social Psychology- Social Cognition Charles de Menezes Case Essay

Social Psychology- Social Cognition Charles de Menezes Case - Essay Example The aim of social cognition is to study the specific aspects that create the mental structure and the process that leads to actions (Bodenhousen, Macrae & Hugenberg 2003, p.257). Man’s behavior towards other people depends on his internal cognitive structure about other people. Every action, whether it is planned or spontaneous, is driven by the social cognitive structure of mind. Hence, it won’t be wrong to say that the killing of Mr. Charles de Menezes, who was shot dead after being mistaken for a terrorist called Hussain Osman (Swaine 2008), was actually not a case of mistaken identity, but was a result of the distortion in the internal cognitive structure of people who were responsible for the killing. Mr. Charles de Menezes was shot seven times in his head by the plain clothes officers, without giving him warning or without making sure that he was the right person (Swaine 2008). The intention of the police operation was to keep a watch of the flats where Osman lived and stop anyone leaving the flats or arrest them quietly for investigation (Bailey 2008). When Mr. Charles de Menezes left the flat, he was folowed by differnt officers to the tube station where he boarded the subway car (Bailey 2008). During this whole process, officers ‘James’, ‘Frank’,‘Ivory’ and ‘Laurence’, who were following Mr. Menezes, were not sure if he was the man they were looking for. In fact ‘Laurence’ told the team that he did not believe the person was identical to the man they were looking for (Bailey 2008). After all these signals from the surveillance officers about Mr. Menezes not being ‘their’

Approaches in Lifelong Learning Essay Example for Free

Approaches in Lifelong Learning Essay The need of the learners was identified as having to have investigators who could adopt a methodical approach, which is essential whilst carrying out equipment failure investigations. This was used as my session aim: ‘This learning session will teach you a methodical approach of investigating equipment failure’. When identifying the need for training I first assessed what the learners would have to have learnt by the end of the learning session. This was identified as the need to know what equipment would be used and how to carryout an investigation in easily managed phases. I then used this as my objective: By the end of this lesson you will have been introduced to the contents of the investigator pack and be able to identify the 3 phases of an equipment failure investigation’. (1. 2) The learners were identified as personnel with some previous learning within the subject matter. The instructional, rather than practical approach to delivering the session was selected as the subject matter was mainly theoretical (the session would later be followed by a practical session). The primary method of delivery would be verbal, given by the teacher.

Murder, Mystery and Intrigue in My Last Duchess Essay -- Robert Browni

Murder, mystery and intrigue all describe Robert Browning's poem, "My Last Duchess." From the speakers' indirect allusions to the death of his wife the reader is easily lead to think that the speaker committed a vengeful crime out of jealousy. His elaborate speech confuses and disguises any possible motives, and the mystery is left unsolved. Even if he did not kill his wife, he certainly has something to hide. Based on the poem's historical references, style and structure, the Duke's controlling and jealous nature becomes evident. An ambiguous quality about the Duke is his historical character. The incident the poem dramatizes clearly references the historical Alfonso II, Duke of Ferrara, who married Lucrezia, daughter of a man who later became pope, the Medici, in 1558 (Rudy 169). Within two years of their marriage she suspiciously died. We know that Browning's Duke has a nine-hundred-years-old name of which he was very proud, and, based on his collections of paintings and sculptures, that he was a patron of arts. Both facts correspond with the historical Duke. The poem's duke of Ferrara, his last duchess, the "Count" with whose servant Ferrara is here discussing re-marring and a dowry, and the new "fair daughter" are also historical, but the interpretation of what actually took place among them is Browning's own. The style and structure of this poem plays a significant role in the effect of the poem. "My Last Duchess" exemplifies the important elements of Browning's talent for dramatic monologue, his ability to evoke the unconstrained reaction of a person in a particular situation or crisis (Bloom 35). This format suits this poem particularly well because the speaker, taken to be Duke of Ferrara, comes across as being v... ... aspects of the Duke that remain unclear include his true character. As mentioned, he is presenting his best side, but through his speech the use of historical references, style, and structure helps the reader sees how he is very jealous and controlling, which leads us to believe he may have many dishonorable qualities. Works Cited Bloom, Harold. Modern Critical Views of Robert Browning. New York: Chelsea House Publishers, 1985. Browning, Robert. "My Last Duchess." Literature: An Introduction to reading and writing. Ed. Edgar V. Roberts. 6th Edition. New Jersey: Prentice-Hall Inc., 2001. 695-697. DeVane, William. A Browning Handbook. New York: Appleton-Century, Inc, 1955. Magill, Frank N., Ed. Magill's Survey of World Literature. 1 vols. New York: Marshall Cavendish Corp. 1993. Rudy, Mary K. Poetry for Students. 1 vols. Detroit: Gale. 1998. 164-171.

Digital Communication Essay

We are now living in a generation where instead of writing a letter we will send an email and instead of making a phone call we will send a text; Digital communication has taken over. Digital Communication is any form of communication that happens through any digital media, For example: Twitter, text, you tube and Facebook. A recent example of how digital communication is taking over our language is Facebook. In 2004 Facebook was made global and now 9 years later, 1 in 7 people in the world have a Facebook account. Living in this generation, I have grown up with these social media sites being part of my life meaning, the language my generation use, such as emoticons, abbreviations and Initialism are classed as a normal way of talking. This new style of expressing the English language too many people may be normal and socially excepted, however by doing this we are constantly breaking the rules of Standard English. For my first example of Digital Communication, I have used Initialism. You can see this in source 1, which is from a Facebook convocation I recently had with a friend. An example of this feature is the term ‘IKR’ (I Know Right). The reason I use Initialism is because writing the first letter of each word, in contrast to writing out in full is a lot easier. In this Facebook chat I had with my friend I had an informal tenor toward him as I know he would not judge me on the way I communicated my words, plus, it was a dyadic convocation meaning it was only between us. Not only did I use this feature but also did my friend, showing, that in this generation features like Initialism is a normal way to talk and is not frowned upon by people of this generation. However people who have not grown up with Digital Communication in their lives believe the Standard English rules must not be broken (Prescriptivists) and therefore will disagree with the way some people express their language as they believe it is the ‘wrong’ way. David Crystal, who is a descriptivist; someone who believes digital communication adds a new form of expression and wont judge the way we communicate, has a theory called linguistic eco nomy which basically means we use features like Initialism because it uses as few characters as possible and therefore saves us time. Crystal also shows how Initialism is not actually a new feature of communication but actually can be dated back to 1689 when the term ‘IOU’ (I Owe you) was first said, this is no different to the way the young society used the term ‘lol’ (Laugh out loud). In digital communication without being able to show facial expression, and hear tone of voice being able to express emotion is hard, however people have overcome this problem. In source 3 (text) emoticons are used, emoticons are used to show emotions without having to write it out. By using the available symbols on phones you are able to produce, faces, love hearts, animals etc. In texts and through all digital media ‘: )’ this ‘face’ means happy and this face ‘: (‘means sad. By adding emoticons to the end of your text or Facebook message the person receiving it knows how you are feeling or how the message was intended. Although this can also lead to misjudgement and pr oblems. Symbols arranged like this ‘

Rhetorical Analysis of Jfk Inaugural Speech Essay

In early 1961, the United States of America was enduring racial tensions and inequalities on the home-front, as well as waging war against Communism and the Cold War internationally. Chaos and fear had penetrated the minds of the American people because the Cold War was near its pinnacle; the American people longed for a strong, reassuring leader. John F. Kennedy provided that reassurance in his Inaugural Address. Taking the current national and international turmoil into account, Kennedy sought to persuade the Nation’s people to Join in his efforts and unify together in order to achieve peace. The inaugural address is saturated with rhetorical strategies seeking to flatter the American People and utilizes words of encouragement to evoke unification. Kennedy was able to effectively establish a profound kairotic moment at which his discourse can make the most difference or have the most influence. The speech persuades the American people by providing motivating propositions through appeals to ethos, logos and pathos. Kennedys inaugural address plays to an irrefutably persuading rhythm. Strong, motivational verbs are Joined with sophisticated adjectives in a manner that would make the most nane speech capable of swaying an entire population. In order to capture the minds of the American people, Kennedy begins with an antithesis, calling his victory, â€Å"†¦ a celebration of freedom-symbolizing an end, as well as a beginning†. This statement is to ensure the people that they are embarking in a new era of reform and peace, the end of turmoil, and the beginning of prosperous tranquility. Similar to the Declaration of Independence, Kennedys speech emphasizes the unification of the country through the use of parallelism and Juxtaposition. Kennedy appeals to his udience’s ethos through visions of freedom and American values. He does this through the Juxtaposition of freedom from the tyranny of man and the reliance of God to provide such freedom. By utilizing a quote from Isaiah, â€Å".. to undo heavy burdens and let the oppressed go free†, Kennedy persuades all who listen to pursue freedom because it is both their God given right and their patriotic duty. Kennedy emphasizes his argument for patriotic unification by effectively using anaphora to break his pledges and propositions into segments. The repetition of declarative lements exemplifies his pledge that he will continue to pursue peace and encourage action. He declares, â€Å"to those new states whom we welcome to the ranks of the free,† and, â€Å"to those peoples in huts and villages across the globe† in order to evokes nationalistic feelings through the appeal to pathos. This pledge of calm persuasiveness exemplifies his stasis of remaining strong and unified amongst the division of tyranny. Kennedys choice of such language caused his audience to find it hard to disagree with such an amiable stance. He stated, â€Å"United, there is little e cannot do in a host of co-operative ventures. Divided, there is little we can do, for we dare not meet a powerful challenge at odds and split asunder†. This statement exemplifies the importance of international and national unification. Due to the Cold War, Kennedy is extremely intent on bringing liberty to the world much more than protecting the liberties already present. However, it is evident that there was an underlying fear in his pledge; almost a plea to advisories for union and non violent where disagreeing with him would seem unpatriotic and weak, â€Å"In your hands, my ellow citizens, more than mine, will rest the final success or failure of our course. Since this country was founded, each generation of Americans has been summoned to give testimony to its national loyalty. The graves of young Americans who answered the call to service surround the globe†. Kennedy chose words such as, â€Å"national loyalty’, in order to evoke an appeal to ethos and logos and â€Å"graves of young Americans† to appeal to their pathos. He points to the resiliency of the United States and the need for the people to continue to support the ideals of freedom that ave seemed forgotten. The people were challenged to â€Å"Let every nation know, whether it wishes us well or ill, that we shall pay any price, bear any burden, meet any hardship, support any friend, oppose any foe, to assure the survival and the success of liberty. † Kennedy successfully appeals to the pathos and ethos of the audience in order to establish his views of the inane strength and duty within all Americans. In the conclusion of his speech, Kennedy cleverly positions one of the most memorable quotes of history. While the audience is full of excitement and atriotic duty because of his previous statement calling for strength and faith, he pauses for a moment and states â€Å"And so, my fellow Americans, ask not what you r country can do for you; ask what you can do for your country. † This statement attenuates itself to the rhetorical instrument of kairos because the placement and the time in which Kennedy chose to speak the words provided its long lasting impact. The influence of this statement has persuading many Americans to act upon their own stasis and exemplify true freedom and strength for their country.

Tg-BRAF transgenic mice Essays

Tg-BRAF transgenic mice Essays Tg-BRAF transgenic mice Essay Tg-BRAF transgenic mice Essay Molecular dissection of papillose thyroid malignant neoplastic disease patterned advance to ill differentiated carcinoma in Tg-BRAF transgenic mice: Evidence for epithelial-mesenchymal passage and designation of campaigner tracts. Abstraction Mice ( Tg-BRAF ) with thyroid-specific look of oncogenic BRAF ( BRAFV600E ) develop papillose thyroid malignant neoplastic diseases ( PTC ) by 3 hebdomads of age. At 5 months gt ; 90 % of PTCs are locally invasive, and ~50 % have well-defined focal point of ill differentiated carcinoma ( PDTC ) . To look into the PTC-PDTC patterned advance in Tg-BRAF mice, we performed a microarray analysis utilizing RNA prepared from cells collected by optical maser gaining control microdissection from mated samples of PDTC and well-differentiated PTC from the same animate being. Analysis of 8 mated samples hybridized to a Operon microarray with a 35473 oligo denseness found 98 cistrons with consistent look alterations between PTC and PDTC in at least 7 of the 8 paired samples. EASE analysis indicated that cistrons involved in cell adhesion and intracellular junctions were significantly represented, with alterations consistent with an epithelial-mesenchymal passage ( EMT ) . Decreased look of E-cad herin and desmocollin 2 and increased look of procollagen and vimentin, all of which are trademarks of EMT, were observed in at least 7 of 8 PDTC focal point. The upregulation of vimentin in PDTC focal point was confirmed by IHC. There were no consistent look alterations in LEF/TCF or in the snail household, proposing that the Wnt and sonic porcupine tracts are non involved in the initiation of EMT, or in patterned advance to PDTC. By contrast, increased look of PDGF-B and/or D was found in all 8 PDTC focal point. As TGF?I look is increased in the thyroids of the Tg-BRAF mice, these informations are consistent with a function for a TGF?-activated autocrine cringle affecting PDGF in EMT. Decreased E-cadherin has besides been observed in human BRAFV600E positive anaplastic carcinomas, proposing that thyroid malignant neoplastic disease patterned advance in worlds may besides affect EMT. Pathways modulating this passage may be of biological and curative involvement. Introduction The BRAFT1799A mutant is the most common familial alteration in PTC. It is non found in any other signifier of well-differentiated follicular tumor ( 1 ) . BRAF mutants can happen early in development of PTC, as they are present in microscopic PTCs ( 2 ) . Most ( 2,3 ) , but non all ( 4 ) , surveies show that PTCs with BRAF mutants present more frequently with extrathyroidal invasion and at a more advanced phase. Tall cell discrepancy PTCs, regarded as more aggressive, have a really high prevalence of BRAF mutant ( 2 ) . Undifferentiated or anaplastic carcinomas originating from preexisting PTCs have a important prevalence of BRAF mutants, whereas those originating from preexisting follicular carcinoma do non ( 2,5 ) . These informations show that BRAF mutants may be an alternate tumor-initiating event in PTC, and that PTCs with this genotype probably carry a worse forecast. The function of oncogenic BRAF as a tumor-initiating event has been confirmed in mice with overexpression of B -RafV600E targeted to thyroid cells by agencies of the thyroglobulin ( Tg ) cistron booster ( 6 ) . Tg-BRAFV600E mice develop PTCs with high penetrance early in life, and advancement to dedifferentiation, capsular and microvascular invasion, corroborating many of the characteristics found in the human tumours. MATERIALS AND METHODS Experimental animate beings: Creation and initial word picture of the Tg-BRAF2 ( mice with thyroid-specific look of BRAFV600E ) have been described ( 6 ) . Mice were house in. All described processs were approved by the institutional carnal commission. Thyroid aggregation and optical maser gaining control. Animals were euthanized with CO2 and thyroids collected and instantly frozen in OTC. Frozen subdivisions were stained with H A ; E and examined by diagnostician ( YN ) for WD and PD malignant neoplastic disease. Twelve consecutive subdivisions ( 7.5 millimeter ) were taken from parts found to hold a PD focal point. The consecutive subdivisions were stained with HistoGeneTM LCM Frozen Section Staining Kit ( Arcturus Bioscience, Inc. , Mountain View, CA ) and cells from PD focal point and a representative part of WD malignant neoplastic disease were isolated utilizing the artsus Arcturus PixCell II optical maser gaining control microscope System. RNA was isolated from the optical maser captured cells utilizing PicoPureTM RNA Isolation Kit Kit ( Arcturus Bioscience, Inc. , Mountain View, CA ) and so subjected to 2 unit of ammunition messenger RNA elaboration utilizing the messageAMP RNA elaboration kit ( Ambion, Austin, TX ) . Microarray analysis. The mouse 70-mer oligonucleotide library version? ? ? consists of? ? ? optimized oligos ( Qiagen ) and was arrayed and printed as antecedently outlined. The complete cistron lists can be viewed at? ? ? . Fluorescence-labeled complementary DNA were synthesized from amplied RNA utilizing an indirect amino allyl labeling method via an oligo ( dT ) -primed, change by reversal RNA polymerase reaction. The complementary DNA were labeledAmplified RNA was with monofunctional reactive cyanine-3 and cyanine-5 dyes ( Cy3 and Cy5 ; Amersham, Piscataway, NJ ) . Pairwise hybridisations were done between labeled complementary DNA matching to unstimulated versus doxycycline-treated cells for each of the cell lines and clip points. In add-on, to increase the statistical power of the experiment, paired hybridisations were done to compare look between cell lines at the same clip points before or after oncoprotein activation. Detailss of hybridisation and rinsing conditions can be found at? ? ? . Imagin g and informations coevals were carried out utilizing a GenePix 4000A and GenePix 4000B ( Axon Instruments, Union City, CA ) and associated package from Axon Instruments, Inc. ( Foster City, CA ) . The microarray slides were scanned with double optical masers with wavelength frequences to excite Cy3 and Cy5 fluorescence emittance. Images were captured in JPEG and TIFF files, and DNA musca volitanss were captured by the adaptative circle cleavage method. Information extraction for a given topographic point is based on the average value for the signal pels minus the average value for the background pels to bring forth a cistron set informations file for all the DNA musca volitanss. The Cy3 and Cy5 fluorescence signal strengths were normalized. Data standardization was done in two stairss for each microarray individually ( 19-21 ) . First, background-adjusted strengths were log transformed, and the differences ( R ) and norms ( A ) of logtransformed values were calculated as R = log2 ( X1 ) log2 ( X2 ) and A = [ log2 ( X1 ) + log2 ( X2 ) ] / 2, where X1 and X2 denote the Cy5 and Cy3 strengths after deducting local backgrounds, severally. Second, informations focus was done by suiting the array-specific local arrested development theoretical account of R as a map of A. The difference between the ascertained log-ratio and the corresponding fitted value represented the normalized log-transformed cistron look ratio. The statistical analysis was done for each cistron individually by suiting a mixed-effects additive theoretical account. Premises about theoretical account variables are the same as described in mention ( 7 ) , with array effects assumed to be random and intervention and dye effects assumed to be fixed. Statistical significance of differential look was assessed by ciphering Ps and seting for multiple hypotheses proving by ciphering false find rates ( 8 ) . Estimates of fold alteration were besides calculated. Data standardization and statistical analyses were done utilizing SAS statistical package bundle ( SAS Institute, Inc. , Cary, NC ) . Gene note was supplemented with human and mouse homologues for unknown oligos. Immunohistochemistry: Animals were euthanized with CO2 and thyroids collected and instantly placed in 4 % PFA. After 24 hours they thyroids were placed in 70 % ethyl alcohol and embedded in. ? ? ? was? . Consecutive subdivisions from part found to incorporate a PD focal point were? ? ? and incubated with indicated antidbodies. Immunoreactive was detected by incubating with and? Consequence Gene look profile of WD and PD thyroid malignant neoplastic diseases from Tg-BRAF mice: Tg-BRAF2 mice develop PTC by 3 hebdomads of age and by 12 hebdomads of the animate beings had locally invasive PTC and about 50 % had focal countries of PDTC ( 6 ) . The PDTC were identified by a solid growing pattern incorporating fusiform cells ( Fig 1A ) . Extra verification that the focal point were PDTC was provided by an increased figure of mitotic ( Fig 1B ) and Ki67 positive cells ( Fig 1C ) every bit good as the presence of necrotic/apoptosis cells ( Fig 1C ) . To place cistron look alterations involved in the passage from the WD PTC to the PDTC we used LCM to insulate cells from from 8 alone ill differentiated focal point and a representative country of WD PTC from the same Tg-BRAF2 mice. RNA was isolated from the optical maser captured cells, amplified, labeled with Cy5 or Cy3 and hybridized to operon? ? ? bit. This identified? ? ? cistrons with important look alterations ( P lt ; 0.05 , FDR lt ; 0.1 ) and of these? ? ? had an look alterations that was greater 1.5 crease. There were? ? ? cistrons merchandises that decreased and? ? ? that increased. To place signaling tracts that may intercede or lend to these look changes we used EASE analysis to compare our informations set to the Gene Ontology and KEGG databases. This found that cistrons involved in tight junction, ? ? and where significantly represented in the PDTC information set. Closer scrutiny indicated that that cistrons involved in tight juntction and cell contact were decreased, while the intermediate filament cistron increased in look ( Table 2 ) . These alterations are consistent with an EMT. To corroborate cells in the PDTC had undergone EMT a 2nd set of thyroids from Tg-BRAF2 animate being were IHC stained for E-cadherin and vimentin, hall Markss of EMT. tracts Mentions 1. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA. High Prevalence of BRAF Mutations in Thyroid Cancer: Familial Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma. Cancer Res 2003 ; 63:1454-7. 2. Nikiforova MN, Kimura ET, Gandhi M, et Al. BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Ill Differentiated Carcinomas Arising from Papillary Carcinomas. J Clin Endocrinol Metab 2003 ; 88:5399-404. 3. Xing M, Westra WH, Tufano RP, et Al. BRAF Mutation Predicts a Poorer Clinical Prognosis for Papillary Thyroid Cancer. J Clin Endocrinol Metab 2005 ; . 4. Puxeddu E, Moretti S, Elisei R, et Al. BRAF ( V599E ) mutant is the taking familial event in grownup sporadic papillose thyroid carcinomas. J Clin Endocrinol Metab 2004 ; 89:2414-20. 5. Namba H, Nakashima M, Hayashi T, et Al. Clinical deduction of hot topographic point BRAF mutant, V599E, in papillose thyroid malignant neoplastic diseases. J Clin Endocrinol Metab 2003 ; 88:4393-7. 6. Knauf JA, Ma X, Smith EP, et Al. Targeted look of BRAFV600E in thyroid cells of transgenic mice consequences in papillose thyroid malignant neoplastic diseases that undergo dedifferentiation. Cancer Res 2005 ; 65:4238-45. 7. Wolfinger RD, Gibson G, Wolfinger ED, et Al. Measuring cistron significance from complementary DNA microarray look informations via assorted theoretical accounts. J Comput Biol 2001 ; 8:625-37. 8. Reiner A, Yekutieli D, Benjamini Y. Identifying differentially expressed cistrons utilizing false find rate commanding processs. Bioinformatics 2003 ; 19:368-75.

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Christopher Brumfits British Studies Essay Example | Topics and Well Written Essays - 500 words

Christopher Brumfits British Studies - Essay Example This research will begin with the statement that â€Å"British Studies† by Christopher Brumfit examines the growing interest in British studies from various points of view— the curriculum developer, teacher-mediator, students from within the UK and from outside, and from an omniscient socio-cultural, economic, political, and philosophical vantage view. As stated by Brumfit, â€Å"†¦ the learners construct their own meanings by a process of engagement with appropriate data.† The writing of this analysis is the researcher's engagement with data. Further, according to Brumfit, â€Å"†¦ construction of effective meaning depends on being able to integrate new understanding with the sets of categories that are already used to deal with the previous experience. This paper illustrates that thus learning depends on the interaction between the new and the old.† The present research has identified that although Brumfit said this within the context of the st udents’ learning about Britain as integrated with the knowledge and understanding they already have, the researcher find it worthy to cite this premise, because it is also within this mindset that he is doing this critical analysis of the generic British studies, not Brumfit’s â€Å"British Studies,† as critical analysis of the latter also invites reading of many other equally interesting sources.... (BritishCouncil.org) The 1991 British Council list of library materials includes books on economics, education, geography, language, law, literature, politics, science, religion, sports and theatre along with customs, food, monarchy, television, and other less serious topics. (Brumfit 45). More than the content of the studies, what matters more is the realistic assessment of what the learners bring to the study in the beginning (Brumfit 51) such as their understanding of their own culture, specifically in the case of foreign students, as well as their understanding of the British culture. Why study Britain To perpetuate the vested interest of the powerful Brumfit's work is full of complexities and ambiguities, presenting so much ideas without sewing them up with a single thread that will unify and conclude into something concrete and optimistic. It is fortunate that clear goals and constant purpose have been achieved by the government for British studies now and up to 2010 and beyond. In the 28-page Making a World of Difference (2006) publication by the British Council, it can be gathered that British studies is intercultural and for the sake of the changing world. The purpose is to build mutually beneficial relationships between people in the UK and other countries. Some 10,000 influential young people in the UK and a range of other countries will have the skills and relationships to take the world community into a new era of intercultural exchange and understanding. British studies has come to mean the study of Britain by foreign students. The policy makers, with the support of universities have intended this to be so because of these crucial 21st century UK imperatives-the growing importance of the relation with China, India, and

Deaf Again Assignment Example | Topics and Well Written Essays - 500 words

Deaf Again - Assignment Example In the case study, Mark was born without this disability but later grew deaf. His parents were deaf. However, the mark was a lucky child since his parents without the use of sign language, which in a way could have interfered with his speech and later affect his studies, educated him. The author states that the parents opted not to use sign language when educating mark. They had the belief that sign will interfere with Mark’s ability to speak. This could later interfere with his level of understanding during education. On the Fence is another collection from the deaf writers that depicts the hidden world that those with hearing disabilities live as a virtually invisible population. The parents and grandmother of Mark feel much proud that Mark is educated without the use of sign language that they believed might interfere with is education. As per the argument of Mark Drolsbaugh, a child should pick up a language at the age of one to two years. This will enable their parents to identify any disability and be in a position to employ corrective measures before the situation is severe. This will also enable the deaf children to establish whether they can pursue learning with or without the use of sign language. The picking of language at this age also establishes a foundation on the education basis, enabling the child to pursue the various aspects of learning like speaking, reading and writing more effectively. Mark, although he was deaf, remained determined. The support he goes from his parents gave him chance to pursue learning and prosper in education. The author regrets his slow growth and development of emotions. It took him so long to appreciate and be proud of the ‘deaf culture’. The deaf people should appreciate themselves and get encouraged that they can still prosper regardless of their disability. After a deaf child is implanted, the parents have a responsibility to support him or her.